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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract: treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognosticfactors of these patients, particularly those who underwent primary debulking surgery followed by platinum-basedanalysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significant factors

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 468-477 doi: 10.1007/s11684-015-0419-6

Abstract: In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with maturestage, elevated serum lactate dehydrogenase level, and BM involvement were independent unfavorable prognosticfactors.The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting

Keywords： mature T-cell lymphoid malignancies     clonal T-cell population     bone marrow infiltration     prognostic factors    

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Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 229-238 doi: 10.1007/s11684-017-0506-y

Abstract:

A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group for adult acute lymphoblastic leukemia (ALL). We retrospectively analyzed 153 newly diagnosed adult patients with Philadelphia chromosome (Ph)-positive ALL enrolled into imatinib (400 mg/d) plus CALLG2008 regimen between 2009 and 2015. The median age was 40 years (range, 18–68 years), with 81 (52.3%) males. The overall hematologic complete remission (CR) rate was 96.7% after induction. With a median follow-up of 24.2 months, the estimated 3-year overall survival (OS) and event-free survival (EFS) rates were 49.5% (95% confidence interval (CI): 38.5%–59.5%) and 49.2% (95% CI: 38.3%–59.2%), respectively. Fifty-eight (36 with haploidentical donor) patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first CR. Among the patients in CR1 after induction, both the 3-year OS and EFS were significantly better in the allo-HSCT group than in the without allo-HSCT group (73.2%, 95% CI: 58.3%–83.5% vs. 22.2%, 95% CI: 8.7%–39.6% and 66.5%, 95% CI: 50.7%–78.2% vs. 16.1%, 95% CI: 5.1%–32.7%, respectively). Multivariate analysis showed that allo-HSCT and achievement of major molecular response were associated with favorable OS or EFS independently. Interestingly, in the allo-HSCT cohort, the donor type (haploidentical versus matched donors) had no significant impact on EFS or OS. All these results suggested that imatinib plus CALLG2008 was an effective protocol for Ph-positive ALL. Haploidentical donors can also be a reasonable alternative expedient donor pool.

Keywords： Philadelphia chromosome     acute lymphoblastic leukemia     imatinib     CALLG2008    

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Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 457-462 doi: 10.1007/s11684-010-0240-1

Abstract: This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen

Keywords： cholangiocarcinoma     prognostic factors     serum carbohydrate antigen 19-9    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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A review of condition-based maintenance: Its prognostic and operational aspects

Yanrong LI, Shizhe PENG, Yanting LI, Wei JIANG

Frontiers of Engineering Management 2020, Volume 7, Issue 3,   Pages 323-334 doi: 10.1007/s42524-020-0121-5

Abstract: Then, we summarize several kinds of prognostic models that use monitoring information to estimate the

Keywords： condition-based maintenance     prognostics     operational decision-making     reliability    

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Four-protein model for predicting prognostic risk of lung cancer

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 618-626 doi: 10.1007/s11684-021-0867-0

Abstract: Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome. Heat-shock protein 90 β (HSP90β) is overexpressed in various tumor cells. In this study, the ELISA results of HSP90β combined with CEA, CA125, and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer. Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high- and low-risk groups. Results suggested that the joint detection of HSP90β, CEA, CA125, and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer.

Keywords： lung cancer     HSP90β     decision tree model     prognosis    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: This study investigated the expression, prognostic value, and role of MID2 in breast cancer.Univariate and multivariate analyses indicated that high MID2 expression was an independent prognosticThis study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: The authors performed a meta-analysis of case-control studies that addressed whether reproductive factorsbreast cancer risk while breast-feeding and number of full-term pregnancies ≥1 are protective factors

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 204-211 doi: 10.1007/s11684-012-0202-x

Abstract: hematologic, cytogenetic, and molecular), overall survival (OS), treatment event-free survival (EFS), and prognosticfactors of outcome.

Keywords： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainThe epidemiological features and factors influencing hospital mortality and renal function recovery wereIncreased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factorsIn addition to traditional risk factors, white blood cell count, platelet count, albumin, and BMI wereNo laboratory indicators were found to be the risk factors of renal function recovery in AKI patients

Keywords： acute kidney injury     risk factors     prognosis    

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Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 94-103 doi: 10.1007/s11684-019-0680-1

Abstract: This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosedimmunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognosticfactors for PFS (P=0.008, P<0.001) and OS (P=0.003, P<0.001).Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P=0.001

Keywords： immunologic marker     diffuse large B-cell lymphoma     prognosis    

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Factors affecting the distribution of microplastics in soils of China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1710-4

Abstract:

● Microplastic (MP) abundance in soil of China was highly heterogeneous.

Keywords： Microplastic distribution     Microplastic heterogeneity     Effecting factors     Agriculture     Socio-economicfactors    

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Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 658-666 doi: 10.1007/s11684-018-0640-1

Abstract: intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factorsIn addition to genetic and biological factors, socioenvironmental factors, including family, school,The complexity of risk factors for developing obesity among children and adolescents leads to difficultyMultifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors

Keywords： obesity     children     adolescents     epidemiology     risk factor     prevention    

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Title Author Date Type Operation

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Journal Article

Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Journal Article

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

A review of condition-based maintenance: Its prognostic and operational aspects

Yanrong LI, Shizhe PENG, Yanting LI, Wei JIANG

Journal Article

Four-protein model for predicting prognostic risk of lung cancer

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Journal Article

Factors affecting the distribution of microplastics in soils of China

Journal Article

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Journal Article